Comparison of fMRI BOLD Response Patterns by Electrical Stimulation of the Ventroposterior Complex and Medial Thalamus of the Rat
Identifieur interne : 000E21 ( Main/Exploration ); précédent : 000E20; suivant : 000E22Comparison of fMRI BOLD Response Patterns by Electrical Stimulation of the Ventroposterior Complex and Medial Thalamus of the Rat
Auteurs : Pai-Feng Yang [Taïwan] ; You-Yin Chen [Taïwan] ; Der-Yow Chen [Taïwan] ; James W. Hu [Canada] ; Jyh-Horng Chen [Taïwan] ; Chen-Tung Yen [Taïwan]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
The objective of this study was to compare the functional connectivity of the lateral and medial thalamocortical pain pathways by investigating the blood oxygen level-dependent (BOLD) activation patterns in the forebrain elicited by direct electrical stimulation of the ventroposterior (VP) and medial (MT) thalamus. An MRI-compatible stimulation electrode was implanted in the VP or MT of α-chloralose-anesthetized rats. Electrical stimulation was applied to the VP or MT at various intensities (50 µA to 300 µA) and frequencies (1 Hz to 12 Hz). BOLD responses were analyzed in the ipsilateral forelimb region of the primary somatosensory cortex (iS1FL) after VP stimulation and in the ipsilateral cingulate cortex (iCC) after MT stimulation. When stimulating the VP, the strongest activation occurred at 3 Hz. The stimulation intensity threshold was 50 µA and the response rapidly peaked at 100 µA. When stimulating the MT, The optimal frequency for stimulation was 9 Hz or 12 Hz, the stimulation intensity threshold was 100 µA and we observed a graded increase in the BOLD response following the application of higher intensity stimuli. We also evaluated c-Fos expression following the application of a 200-µA stimulus. Ventroposterior thalamic stimulation elicited c-Fos-positivity in few cells in the iS1FL and caudate putamen (iCPu). Medial thalamic stimulation, however, produced numerous c-Fos-positive cells in the iCC and iCPu. The differential BOLD responses and c-Fos expressions elicited by VP and MT stimulation indicate differences in stimulus-response properties of the medial and lateral thalamic pain pathways.
Url:
DOI: 10.1371/journal.pone.0066821
PubMed: 23826146
PubMed Central: 3691267
Affiliations:
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Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Der Yow" sort="Chen, Der Yow" uniqKey="Chen D" first="Der-Yow" last="Chen">Der-Yow Chen</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Psychology, National Cheng Kung University, Tainan City, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Psychology, National Cheng Kung University, Tainan City</wicri:regionArea><wicri:noRegion>Tainan City</wicri:noRegion></affiliation></author><author><name sortKey="Hu, James W" sort="Hu, James W" uniqKey="Hu J" first="James W." last="Hu">James W. Hu</name><affiliation wicri:level="4"><nlm:aff id="aff4"><addr-line>Faculty of Dentistry, University of Toronto, Toronto, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Dentistry, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Chen, Jyh Horng" sort="Chen, Jyh Horng" uniqKey="Chen J" first="Jyh-Horng" last="Chen">Jyh-Horng Chen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Interdisciplinary MRI/MRI Lab, Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Interdisciplinary MRI/MRI Lab, Department of Electrical Engineering, National Taiwan University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Neurobiology and Cognitive Science Center, National Taiwan University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Yen, Chen Tung" sort="Yen, Chen Tung" uniqKey="Yen C" first="Chen-Tung" last="Yen">Chen-Tung Yen</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Neurobiology and Cognitive Science Center, National Taiwan University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Institute of Zoology, National Taiwan University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Zoology, National Taiwan University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The objective of this study was to compare the functional connectivity of the lateral and medial thalamocortical pain pathways by investigating the blood oxygen level-dependent (BOLD) activation patterns in the forebrain elicited by direct electrical stimulation of the ventroposterior (VP) and medial (MT) thalamus. An MRI-compatible stimulation electrode was implanted in the VP or MT of α-chloralose-anesthetized rats. Electrical stimulation was applied to the VP or MT at various intensities (50 µA to 300 µA) and frequencies (1 Hz to 12 Hz). BOLD responses were analyzed in the ipsilateral forelimb region of the primary somatosensory cortex (iS1FL) after VP stimulation and in the ipsilateral cingulate cortex (iCC) after MT stimulation. When stimulating the VP, the strongest activation occurred at 3 Hz. The stimulation intensity threshold was 50 µA and the response rapidly peaked at 100 µA. When stimulating the MT, The optimal frequency for stimulation was 9 Hz or 12 Hz, the stimulation intensity threshold was 100 µA and we observed a graded increase in the BOLD response following the application of higher intensity stimuli. We also evaluated c-Fos expression following the application of a 200-µA stimulus. Ventroposterior thalamic stimulation elicited c-Fos-positivity in few cells in the iS1FL and caudate putamen (iCPu). Medial thalamic stimulation, however, produced numerous c-Fos-positive cells in the iCC and iCPu. The differential BOLD responses and c-Fos expressions elicited by VP and MT stimulation indicate differences in stimulus-response properties of the medial and lateral thalamic pain pathways.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Treede, Rd" uniqKey="Treede R">RD Treede</name></author><author><name sortKey="Kenshalo, Dr" uniqKey="Kenshalo D">DR Kenshalo</name></author><author><name sortKey="Gracely, Rh" uniqKey="Gracely R">RH Gracely</name></author><author><name sortKey="Jones, Ak" uniqKey="Jones A">AK Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuo, Cc" uniqKey="Kuo C">CC Kuo</name></author><author><name sortKey="Yen, Ct" uniqKey="Yen C">CT Yen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuo, Cc" uniqKey="Kuo C">CC Kuo</name></author><author><name sortKey="Chiou, Rj" uniqKey="Chiou R">RJ Chiou</name></author><author><name 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Toronto</li></orgName></list><tree><country name="Taïwan"><noRegion><name sortKey="Yang, Pai Feng" sort="Yang, Pai Feng" uniqKey="Yang P" first="Pai-Feng" last="Yang">Pai-Feng Yang</name></noRegion><name sortKey="Chen, Der Yow" sort="Chen, Der Yow" uniqKey="Chen D" first="Der-Yow" last="Chen">Der-Yow Chen</name><name sortKey="Chen, Jyh Horng" sort="Chen, Jyh Horng" uniqKey="Chen J" first="Jyh-Horng" last="Chen">Jyh-Horng Chen</name><name sortKey="Chen, Jyh Horng" sort="Chen, Jyh Horng" uniqKey="Chen J" first="Jyh-Horng" last="Chen">Jyh-Horng Chen</name><name sortKey="Chen, You Yin" sort="Chen, You Yin" uniqKey="Chen Y" first="You-Yin" last="Chen">You-Yin Chen</name><name sortKey="Yang, Pai Feng" sort="Yang, Pai Feng" uniqKey="Yang P" first="Pai-Feng" last="Yang">Pai-Feng Yang</name><name sortKey="Yen, Chen Tung" sort="Yen, Chen Tung" uniqKey="Yen C" first="Chen-Tung" last="Yen">Chen-Tung Yen</name><name sortKey="Yen, Chen Tung" sort="Yen, Chen Tung" uniqKey="Yen C" first="Chen-Tung" last="Yen">Chen-Tung Yen</name></country><country name="Canada"><region name="Ontario"><name sortKey="Hu, James W" sort="Hu, James W" uniqKey="Hu J" first="James W." last="Hu">James W. 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